Tuesday, October 13, 2009

HIV & AIDS - Treatment and Care

HIV testing



A sex worker taking an HIV test

HIV testing provides the gateway to accessing other services; a person living with HIV cannot receive any care until they have been diagnosed. The conventional model is VCT (voluntary counselling and testing), requiring people to come forward to be tested. Recent years have seen increasing promotion of routine testing as well. Under this system, everyone attending certain healthcare facilities – for example antenatal clinics, sexual health clinics or doctors’ surgeries – is routinely tested for HIV unless they refuse.
Early diagnosis enables more effective treatment and care. If HIV is first detected in the late stages of infection then more complex care may be needed, and there is less chance that treatment will work. Early diagnosis also reduces the risk of onward transmission; once someone knows they have HIV they are more likely to take precautions to avoid infecting others.


Counselling and psychosocial support

Receiving an HIV positive test result can be traumatic. Psychosocial support aims to help HIV positive people and their caregivers cope with psychological distress, adjust to change and resume a normal life. Patients who receive good quality counselling are less likely to develop serious mental health problems. Health workers should be able to provide psychosocial support, and additional care can come from trained volunteers or AIDS service organisations.

Support is also crucial to the success of any medical treatment. People should understand why and how HIV-related illnesses should be treated, and should be informed of what forms of treatment and care are available locally and how to access them.

Malnourishment hastens the progression from HIV infection to AIDS and death. Nutritional counselling can enable people to stay healthy for longer, delaying the point at which they need to begin antiretroviral therapy.

Prevention of onward transmission

HIV positive people should receive counselling to help prevent them transmitting HIV to other adults. This means promoting safer sexual behaviour through condom use, fidelity and voluntary abstinence. Counsellors should ask about partners who might be at risk of HIV infection, and discuss how these partners may be notified.

Some sexually transmitted diseases – most notably genital herpes – can increase the risk of HIV transmission. It is therefore particularly important that people diagnosed with HIV receive treatment for any other sexually transmitted infections they might have.

Mother-to-child transmission of HIV can occur during pregnancy, at the time of delivery, and after birth through breastfeeding. Antiretroviral drugs and safer infant feeding can greatly reduce the risk of a baby becoming infected. Pregnant women with HIV must be diagnosed early to receive the maximum benefit, including education and counselling on prevention methods.

Protection from stigma and discrimination

Stigma and discrimination are triggered by many factors, including lack of understanding of the disease, myths about how HIV is transmitted, prejudice, lack of treatment and social fears. These negative attitudes can deter HIV infected people from getting tested, contribute to them infecting others, and prevent them receiving adequate care and treatment.
The involvement of people living with HIV/AIDS in activities for reducing stigma and discrimination is essential. Having people speak openly about their HIV status is one of the first steps to be taken in tackling stigma and discrimination. This can make people realise that HIV is part of their community and not just “someone else's problem”. In addition, the role of people who are HIV negative should not be underestimated. HIV negative people who speak out about HIV/AIDS can help to promote wider support for those who are infected.

TREATMENT OF TB

Today, the treatment of tuberculosis consists of drug therapy and methods to prevent the spread of infectious bacilli. Historically, treatment of tuberculosis consisted of long periods, often years, of bed rest and surgical removal of useless lung tissue. In the 1940s and ’50s several antimicrobial drugs were discovered that revolutionized the treatment of patients with tuberculosis. As a result, with early drug treatment, surgery is rarely needed. The most commonly used antituberculosis drugs are isoniazid and rifampicin (rifampin). These drugs are often used in various combinations with other agents, such as ethambutol, pyrazinamide, or rifapentine, in order to avoid the development of drug-resistant bacilli. Patients with strongly suspected or confirmed tuberculosis undergo an initial treatment period that lasts two months and consists of combination therapy with isoniazid, rifampicin, ethambutol, and pyrazinamide. These drugs may be given daily or two times per week. The patient is usually made noninfectious quite quickly, but complete cure requires continuous treatment for another four to nine months. The length of the continuous treatment period depends on the results of chest X-rays and sputum smears taken at the end of the two-month period of initial therapy. Continuous treatment may consist of once daily or twice weekly doses of isoniazid and rifampicin or isoniazid and rifapentine.




If a patient does not continue treatment for the required time or is treated with only one drug, bacilli will become resistant and multiply, making the patient sick again. If subsequent treatment is also incomplete, the surviving bacilli will become resistant to several drugs. Multidrug-resistant tuberculosis (MDR TB) is a form of the disease in which bacilli have become resistant to isoniazid and rifampicin. MDR TB is treatable but is extremely difficult to cure, typically requiring two years of treatment with agents known to have more severe side effects than isoniazid or rifampicin. Extensively drug-resistant tuberculosis (XDR TB) is a rare form of MDR TB. XDR TB is characterized by resistance to not only isoniazid and rifampin but also a group of bactericidal drugs known as fluoroquinolones and at least one aminoglycoside antibiotic, such as kanamycin, amikacin, or capreomycin. Aggressive treatment using five different drugs, which are selected based on the drug sensitivity of the specific strain of bacilli in a patient, has been shown to be effective in reducing mortality in roughly 50 percent of XDR TB patients. In addition, aggressive treatment can help prevent the spread of strains of XDR TB bacilli.




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